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Breakthrough in Breast Cancer Treatment: Potential Benefits of Diabetes Medication

by Development PRT on 0 Comments

Breast cancer is a formidable disease that affects numerous women worldwide. Among its various forms, triple-negative breast cancer (TNBC) is particularly aggressive and challenging to treat. TNBCs constitute approximately 10 to 15 percent of all breast cancers and are known to disproportionately impact African American and Hispanic women, young women, and those with BRCA1 gene mutations.

Traditionally, chemotherapy has been the primary treatment option for TNBC due to the limited alternatives available. However, a recent study published in the esteemed journal Nature on March 6 revealed promising results that suggest the potential effectiveness of two existing drugs in improving outcomes for TNBC patients. These drugs are metformin, a commonly used diabetes medication, and heme, a medication typically prescribed for rare disorders.

Metformin, commonly prescribed for type 2 diabetes, has been recognized for its anti-cancer effects in recent studies. It has shown the ability to suppress tumor growth and induce cancer cell death in individuals taking the medication. However, the response to metformin varies among different types of cancer cells, and there is currently no reliable marker to predict who might benefit from this treatment.

The research team, led by Marsha Rosner, PhD, a professor in the Ben May Department for Cancer Research at the University of Chicago, sought to address this challenge. Their study focused on heme, a drug marketed as Panhematin and primarily used to treat porphyrias, a group of rare disorders affecting the skin or nervous system. The team discovered that heme could inhibit the production of a protein called BACH1, which is highly expressed in TNBCs and plays a significant role in their aggressive nature.

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Through bioinformatics analysis of patient data, the researchers observed that reducing levels of BACH1 using heme made TNBC tumor cells more susceptible to metformin. They conducted experiments on a mouse model of TNBC and found that the combination of heme and metformin resulted in reduced tumor growth. These findings suggest that heme may serve as a potential pretreatment to enhance the effectiveness of metformin in TNBC treatment.

While further research is necessary to study the combined effects of heme and metformin in human subjects, initial results are promising. Dr. Alice Police, the regional director of breast surgery at Northwell Health Cancer Institute, considers these findings potentially groundbreaking. The two medications already have excellent safety profiles and minimal side effects compared to traditional chemotherapy or immunotherapy drugs. This discovery opens doors to a new, less toxic treatment approach for TNBC patients.

It is crucial to highlight the importance of early diagnosis and treatment for TNBC. As with other types of breast cancer, early detection significantly improves prognosis and treatment outcomes. Regular mammograms play a pivotal role in identifying breast cancer at its earliest stages, making it easier to treat. The U.S. Preventive Services Task Force (USPSTF) recommends that women between the ages of 50 and 74 undergo mammography every two years. However, individual circumstances may warrant starting mammography screening at a younger age. The USPSTF also encourages genetic risk assessments for women with a family or personal history of breast, ovarian, tubal, or peritoneal cancers, particularly those associated with BRCA1 or BRCA2 gene mutations.

The potential benefits of combining metformin and heme in TNBC treatment bring hope for a more effective and less toxic approach. Continued research and clinical trials will shed further light on this promising development, offering new possibilities for TNBC patients and potentially impacting the treatment of other cancers where BACH1 expression is significant.

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